(P 113) ASSESSING TREATMENT OUTCOMES OF CHONDROMYXOID FIBROMA: A CASE SERIES

Objective: Chondromyxoid fibroma (CMF) is a rare, benign, and locally aggressive bone tumor that presents diagnostic challenges due to its radiologic similarity to other lesions. While surgical intervention remains the primary treatment strategy, recurrence rates vary, and there is a lack of standardized treatment guidelines in the literature.

Methods: We conducted a retrospective review of patients diagnosed with CMF at our institution between 2010 and 2024. Eight patients met inclusion criteria, with treatment modalities including en-bloc resection (n=2), intralesional curettage with adjuvants (n=4), and conservative management with serial imaging (n=2). Demographic, clinical, and treatment-related data were collected, and outcomes were analyzed.

Results: The cohort consisted of three males and five females, with a mean age of 55.3 ± 11.8 years and an average follow-up of 41.7 ± 28.5 months. Lesions were located in the distal femur (n=3), pelvis (n=2), clavicle (n=1), great toe (n=1), and T3 vertebral body (n=1). All surgical patients remained free of tumor recurrence, regardless of treatment modality. Two patients treated with en-bloc resection experienced surgical complications requiring revision arthroplasty. Conservative management with serial imaging was successful in asymptomatic patients, with no evidence of disease progression.

Conclusion: This case series demonstrates that en-bloc resection, intralesional curettage with adjuvants, and conservative management with serial imaging are viable options for managing CMF, depending on patient specific factors. Notably, this is the first series to describe successful conservative management with serial imaging of CMF. Our results add to the limited literature on CMF and propose that serial imaging could be a potential management strategy in select patients with CMF.