Associate Professor of Surgery, Harvard Medical School
Massachusetts General Hospital
bOSTON, Massachusetts, United States
Xinhui Wang, MD. Ph.D., is an Associate Professor of Surgery at Harvard Medical School and Associate Immunologist of Surgery at Massachusetts General Hospital. She published extensively on antibody- or T-cell based immunotherapy, targeting radiation and chemo-resistant cancer stem cells. Her laboratory's primary research initiatives center around immunotherapy and radiotherapy for various types of cancers. One of the central focuses of her laboratory is developing non-genetically reprogrammed chimeric antigen receptor (CAR) T cells and modulating the tumor microenvironment to overcome the major barriers facing CAR T therapy in solid tumors. Her team also investigates strategies to enhance standard radiation and chemotherapy through repurposed drugs that induce immunogenic cell death, targeting not only bulk tumor cells but also therapy-induced senescent cells and cancer stem cells. She serves as the Principal Investigator on multiple NIH and Department of Defense (DOD) Prostate Cancer Research Program (PCRP) and Kidney Cancer Research Program (KCRP)–funded projects focused on preventing post-therapy breast cancer metastasis and developing low-dose radiation–based ex vivo reprogramming and activation of CAR T cells targeting B7-H3 in prostate cancer, as well as a cancer in situ vaccine approach for renal carcinoma.
Paper 36 - TARGETING CANCER STEM CELLS AND THERAPY-INDUCED SENESCENT CELLS IN CHORDOMA
Friday, November 14, 2025
10:30 AM - 12:00 PM EST
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