Assistant Member Research
Providence Cancer Institute
Jianguo Huang, PhD is an Assistant Member in the Earle A. Chiles Research Institute at the Providence Cancer Institute, where he leads a laboratory focused on developing therapeutic strategies for rare and understudied cancers. His research aims to uncover the molecular mechanisms driving tumor initiation, progression, and metastasis, with the ultimate goal of identifying safe and effective targeted and immune therapies. Dr. Huang’s expertise spans cancer biology, non-coding genomes, and the development of genetically engineered mouse models of sarcoma. His academic training is complemented by industry experience from 2019 to 2022, where he gained advanced skills in tumor immunology and adoptive cell therapy engineering. This multidisciplinary background enables him to approach cancer research from both mechanistic and translational perspectives. Since establishing his independent lab in 2022, Dr. Huang has focused on dissecting the genetic drivers, signaling pathways, and immune microenvironments that contribute to cancer development and metastasis. His work emphasizes precision medicine approaches tailored to the unique biology of rare tumors. A key achievement of his lab is the creation of innovative primary mouse models that closely mimic human sarcomas. These models serve as powerful platforms for preclinical testing of targeted therapies and immunotherapy combinations, accelerating the path from discovery to clinical application. Dr. Huang’s research is driven by a commitment to improving outcomes for patients with rare cancers through scientific innovation and collaborative translational efforts.
