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Trials in Progress and Late Breaking Clinical Trials

(P 441) COLOSARC-Q: A PROSPECTIVE MULTICENTER STUDY FOR EVALUATING SURGICAL STRATEGIES FOR COLORECTAL RESECTIONS AND POSTOPERATIVE QUALITY OF LIFE IN RETROPERITONEAL SARCOMA PATIENTS

    Author(s)

  • Madelaine Hettler, MD (she/her/hers)

    Resident
    Sarcoma Unit, Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University
    Mannheim, Baden-Wurttemberg, Germany

    • Co-Author(s)

  • KS

    Katrin R. Scharpf, Dr. phil.

    Psycho-oncology service in cooperation with the Central Institute for Mental Health Mannheim, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University
    Mannheim, Baden-Wurttemberg, Germany

  • AE

    Anna Eich, n/a

    Sarcoma Unit, Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University
    Mannheim, Baden-Wurttemberg, Germany

  • MA

    Markus Albertsmeier, MD

    Department of General, Visceral and Transplantation Surgery, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
    Munich, Bayern, Germany

  • AD

    Anna Duprée, MD

    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    Hamburg, Hamburg, Germany

  • SH

    Svetlana Hetjens, Dr.

    Department of Medical Statistics and Biomathematics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Mannheim, Baden-Wurttemberg, Germany

  • Melissa Harbrücker, MD (she/her/hers)

    Resident
    Sarcoma Unit, Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University
    Mannheim, Baden-Wurttemberg, Germany

  • Franka Menge, MD

    Dr.
    Sarcoma Unit, Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University
    Mannheim, Baden-Wurttemberg, Germany

  • AB

    Alexander Betzler, MD

    Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University
    Mannheim, Baden-Wurttemberg, Germany

  • CR

    Christoph Reissfelder, MD

    Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University
    Mannheim, Baden-Wurttemberg, Germany

  • PH

    Peter Hohenberger, N/A, MD

    Sarcoma Unit, Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University
    Mannheim, Baden-Wurttemberg, Germany

  • Jens Jakob, MD (he/him/his)

    Consultant Sarcoma Surgeon
    Sarcoma Unit, Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University
    Mannheim, Baden-Wurttemberg, Germany

Objective: Retroperitoneal sarcomas (RPS) are rare malignancies frequently requiring extensive surgery including colorectal resections for complete tumor removal. Complication rates – including anastomotic leakage – are high, but surgical strategies for colorectal reconstruction remain poorly defined. The prospective COLOSARC-Q study investigates the impact of colorectal interventions during RPS surgery and the health-related quality of life (HRQoL), with the aim of optimizing surgical strategies and supporting shared decision-making.

Methods: COLOSARC-Q is a prospective, multicenter, non-interventional study that will enroll 120 patients with primary RPS undergoing colorectal resection as part of sarcoma surgery at specialized sarcoma centers in Germany or Switzerland. HRQoL will be assessed using validated questionnaires (EORTC QLQ-C30 and -CR29) and semi-structured interviews conducted in collaboration with psycho-oncology services and patient advocates. Clinical data will be collected through electronic case report forms and will include demographic, clinical, surgical, and outcome-related variables.
The primary objective is to evaluate surgical approaches to colorectal resection and reconstruction. Secondary endpoints include postoperative complications, tumor characteristics, and patient-related factors.

Results: Abdominal symptoms as well as stoma formation can significantly impact the HRQoL of cancer patients. In colorectal cancer surgery, factors like age, malnutrition, neoadjuvant therapy, and blood loss influence complications like anastomotic leakage and mortality. The study results could offer insights into whether the same factors apply to sarcoma surgery; however, it is essential to ensure that these factors are integrated into the shared decision-making process for both surgical and multimodal treatment planning.

Conclusion: COLOSARC-Q aims to provide valuable insights into colorectal resections during surgery for retroperitoneal sarcomas, focusing on reducing complications, improving surgical strategies, and enhancing patient HRQoL.