(P 350) THE PATTERN.ORG SARCOMA CONSORTIUM: BUILDING A MULTI-INSTITUTIONAL DATA RESOURCE FOR THE SARCOMA RESEARCH COMMUNITY

Objective: Sarcomas are rare, heterogeneous cancers with poor outcomes. Molecularly focused research has led to breakthroughs, notably afami-cel in synovial sarcoma and nab-sirolimus in PEComa. To accelerate more advances, a comprehensive database that can accommodate detailed histological, clinical, and molecular characterization, with robust biobanking infrastructure, is needed. While many academic centers have internal registries, these are not multi-institutional and do not account for all types of translational data, limiting sample size and utility. Pattern.org, an initiative of the Rare Cancer Research Foundation (RCRF), has partnered with community and academic institutions and patients to provide fresh tissue collection, biobanking logistics, and specialized software for multi-omic clinico-molecular data collection, aggregation, and harmonization.

Methods: Sarcoma patients across the US were recruited and consented. The Pattern biologistics team arranged for fresh tissue transfer to research labs, while clinical records and molecular results were ingested directly into the RCRF research ecosystem by the Pattern team. Partnerships with the University of North Carolina (UNC) through an internal registry, and Parker Institute for Cancer Immunotherapy (PICI) through their AMADEUS trial, have added additional data.

Results: Pattern collected 110 fresh sarcoma tissue samples from 54 centers across the US and delivered them to partner research labs. 61% were female with an average age of 54, 22% had molecular sequencing and clinical records. The UNC cohort added 269 patients seen by sarcoma medical oncology in 2024. The average age was 56 years, 62.5% were female, and 42.8% had molecular sequencing. The PICI cohort added 9 sarcoma patients of various types treated with CTLA-4 + PD-1 with comprehensive longitudinal multi-omic data.

Conclusion: This pilot sarcoma data consortium project combined efforts from RCRF, UNC and PICI. These data offer some preliminary insights into the cohort, but we seek additional partners to facilitate a multi-institutional consortium around sarcoma sample and data collection and sharing. We plan to bring additional institutions in as we expand this resource in the coming year.