(P 369) CLINICAL CHARACTERISTICS & TREATMENT OUTCOME PATTERNS OF SOLITARY FIBROUS TUMORS: A SINGLE-INSTITUTION RETROSPECTIVE ANALYSIS

Objective: Solitary Fibrous Tumors (SFT) are rare soft tissue neoplasms characterized by heterogeneous clinical behavior, making prognosis and treatment challenging. This retrospective study aims to evaluate clinical characteristics, treatment patterns, recurrence rates, and survival outcomes in patients diagnosed with SFT at a single institution.

Methods: We conducted a retrospective analysis of 107 patients diagnosed with SFT. Patient demographics (age, sex, ethnicity, race), tumor characteristics (location, grade, metastatic status at diagnosis), treatment modalities (surgery, radiation, systemic therapy), recurrence patterns, and survival outcomes were collected and analyzed using descriptive statistics.

Results: The cohort consisted predominantly of non-Hispanic (52.3%) patients, with a median age at diagnosis of 61 years (range 24–94). Primary tumor sites most frequently included chest (24.3%), head/neck (21.5%), and extremities (15.9%). Tumor grades were evenly split between high and low grade (12.1% each). At diagnosis, metastatic disease was present in 12.1% of patients, and recurrence occurred in 11.2% of patients. Surgical resection was the mainstay of treatment, with selected cases receiving radiation or systemic therapy. Descriptive trends indicated that recurrence occurred more commonly among patients without initial metastasis, possibly reflecting extended survival and prolonged surveillance.

Conclusion: This single-institution retrospective analysis highlights the clinical heterogeneity and challenges associated with managing SFT. Surgical resection remains central to treatment, complemented selectively by radiation or systemic therapies. The absence of association between initial metastatic status and recurrence underlines the complexity of SFT behavior and emphasizes the importance of long-term surveillance. Future studies focusing on detailed risk stratification and targeted therapies are necessary to further optimize patient outcomes.

Patient Demographics and Clinical Characteristics of the Solitary Fibrous Tumor Cohort (Nf110)